Effect of Body Position on High-resolution Esophageal Manometry Variables and Final Manometric Diagnosis

Article information

J Neurogastroenterol Motil. 2020;26(3):335-343
Publication date ( electronic ) : 2020 July 1
doi : https://doi.org/10.5056/jnm20010
Division of General and Foregut Surgery, Department of Biomedical Sciences for Health, University of Milano, IRCCS Policlinico San Donato Milanese, Milano, Italy
*Correspondence: Luigi Bonavina, MD, IRCCS Policlinico San Donato, Via Morandi 30, 20097 San Donato Milanese, Milano, Italy, Tel: +39-0252774840, Fax: +39-3472601004, E-mail: luigi.bonavina@unimi.it
received : 2020 January 20, accepted : 2020 May 10.

Abstract

Background/Aims

According to the Chicago classification version 3.0, high-resolution manometry (HRM) should be performed in the supine position. However, with the patient in the upright/sitting position, the test could more closely simulate real-life behavior and may be better tolerated. We performed a systematic review of the literature to search whether the manometric variables and the final diagnosis are affected by positional changes.

Methods

A literature search was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statement. Studies published in English that compared HRM results in different body positions were included. Moreover, the change in diagnosis of esophageal motility disorders according to the shift of body position was investigated.

Results

Seventeen studies including 1714 patients and healthy volunteers met the inclusion criteria. Six studies showed a significant increase in lower esophageal sphincter basal pressure in the supine position. Integrated relaxation pressure was significantly higher in the supine position in 10 of 13 studies. Distal contractile index was higher in the supine position in 9 out of 10 studies. One hundred and fifty-one patients (16.4%) out of 922 with normal HRM in the supine position were diagnosed with ineffective esophageal motility (IEM) when the test was performed in the upright position (P < 0.001).

Conclusions

Performing HRM in the upright position affects some variables and may change the final manometric diagnosis. Further studies to determine the normal values in the sitting position are needed.

Introduction

High-resolution manometry (HRM) is considered the test of choice to evaluate esophageal motility disorders. The first sets of normal values were established in 2006.1-3 The normative values (5th and 95th percentiles) were obtained in 75 healthy volunteers studied in the supine position with a solid-state manometric assembly with 36 circumferential sensors spaced at 1-cm intervals and ten 5-mL water swallows in each subject. A subsequent study performed on 400 patients4 allowed a classification of esophageal motility disorders, namely the Chicago classification, that has been updated and has now reached the third version.5 Normative thresholds can vary according to the HRM software system, catheter outer-diameter, bolus consistency and volume, age, obesity, ethnicity, and body position.6 Cutoffs for abnormality established in the supine position may not be valid in the upright/sitting position. Historically also, the conventional water-perfused esophageal manometry was performed with the patient lying in the supine position, which allowed to test the peristaltic function without interference of gravity on bolus transit.7 However, swallowing in the upright position is more similar to real-life behavior, may be more tolerable for patients with swallowing difficulties, and may reduce cardiovascular artifacts on the HRM tracing.8 The aim of this study is to perform a systematic review on comparative studies testing the results obtained during HRM in supine and upright/sitting positions and to search whether HRM variables are influenced by body location and may change the final diagnosis.

Methods

We conducted a systematic review according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statement. An extensive literature search was conducted by 5 independent authors (C.G.R., D.F., M.C., M.S., and S.S.) to identify all clinical reports dealing with results of HRM comparing the supine and upright positions. PubMed, Cochrane, Embase, and Scopus databases were queried using the following terms: “body position”, “esophageal manometry”, “high resolution manometry”, “HRM”, and every possible combination with AND/OR. The search was restricted to studies published in English and was completed by consulting the listed references of each article. Studies with conventional esophageal manometry, and those assessing solid swallows, or which focused on upper esophageal sphincter parameters, or performed during general anesthesia, were excluded. Disagreements among authors were resolved by consensus; if no agreement could be reached, the senior author (L.B.) made the decision. For each selected study, data extracted included first author name, year of publication, nation where the study was performed, number of subjects involved, and whether they were healthy volunteers or symptomatic gastroesophageal reflux disease patients. The following parameters were recorded: protocol characteristics (angle of supine and upright position, number of swallows per set, water amount per swallow expressed in mL, catheter outer-diameter expressed in mm, and software used for data elaboration); upper esophageal sphincter characteristics, including basal pressure and residual pressure; lower esophageal sphincter (LES) characteristics, including basal pressure, integrated relaxation pressure (IRP), total and intra-abdominal length; and esophageal body characteristics, including distal contractile integral (DCI), intrabolus pressure (IBP), distal latency, mean peristaltic pressure, contractile pattern with percentage of failed, weak and rapid swallows, large and small breaks, and double-peak swallow. Lastly we reported the percentage of effective swallows and the change in diagnosis of esophageal motility disorders according to the shift of body position.

The methodological quality of the studies was assessed based on the most critical factors that increase the risk of bias in this specific context.9 Statistical analysis was performed using the SPSS software version 23 (IBM, Armonk, NY, USA). The rate of patients with ineffective esophageal motility (IEM) in the supine versus upright position was compared using Chi-Square Test, and the statistical significance was established at less than the 0.05 level.

Results

Ninety publications were found applying the search criteria. Twenty-seven publications were duplicated and were removed. Sixty-three studies were examined and further screening revealed that only 17 articles met the inclusion criteria (Figure). All included studies were designed as case-series and had a low to moderate risk for bias based on a global assessment of methodological quality.9

Figure

The Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) diagram. UES, upper esophageal sphincter.

High-resolution Manometry Protocols

One thousand seven hundred fourteen patients were included,10-26 of whom 1284 were symptomatic and 430 asymptomatic individuals. The sequence of the position assumed during HRM was described in almost all studies. Some authors referred that the exam was started in the supine position and the subsequent series of swallows was performed in the sitting/upright position;12,14,15,18,19,24 other referred the opposite.16,20,22,23 Patients were randomly assigned both to the upright or supine position in the studies by Zhang et al17,21 and Misselwitz et al.26 Only 5 studies14,16,17,19,24 reported the inclination assumed by the patient during the exam: between 0° and 20° for the supine position and between 75° and 90° for the upright/sitting position. Every study included at least 5 water bolus swallows per set for each position. Data were analyzed using various manometric softwares: 12 studies11-14,16,17,19-21,24-26 used Manoscan (of whom 3 and 9 from Medtronic [Minneapolis, MN, USA]), 3 studies15,22,23 used Bioview by Sandhill Scientific Inc (Ranch, CO, USA), and 2 studies10,18 used Trace! V1.2 videomanometry system (Hebbard System, Melbourne, Australia) (Table 1).

Patients Characteristics and High-resolution Manometry Protocol Features

High-resolution Manometry Variables

In regard to LES parameters, LES length was analyzed in 5 studies,11,15,19,21,23 3 of which15,21,23 found a greater LES length in the supine position. Six15,20,21,23,24,26 of 8 studies11,12,15,20,21,23,24,26 showed a significant increase in LES basal pressure in the supine position, 3 studies11-13 did not find differences, and one19 found a significantly higher pressure in the upright position. IRP was significantly higher in the supine position in 10 of 13 studies,14-17,20-24,26 while in 2 studies13,18 it was significantly increased in the upright position.

In regard to esophageal body parameters, DCI was higher in the supine position in 9 of 10 studies.12,13,16-18,20,22-24,26 In the study by Besanko et al,18 DCI value was significantly higher in the upright position in the subgroup of older healthy patients. Six studies11-13,15,18,20 investigated mean peristaltic wave pressure: it was significantly higher in the supine position in 2 studies,12,20 comparable in 3 studies,11,13,15 and significantly higher in the upright position in 1 study.18 IBP was significantly higher in the supine position in 3 studies,20,23,24 whilst it was comparable in the 2 positions in 1 study.13 Lastly, distal latency was investigated in 7 studies16,17,20-24,26 and was significantly higher in the supine position in 4 studies.16,17,20,24 The HRM values recorded in healthy subjects are summarized in Table 2.

High-resolution Manometry Findings in Healthy Subjects

Concordance of Final Manometric Diagnosis

Only 6 studies10,12,14,20,24,26 for a total of 922 patients reported the difference in terms of final diagnosis in the 2 positions. One hundred and fifty-one patients (16.4%) with normal HRM in the supine position were diagnosed with IEM when the test was performed in the upright position (P < 0.05). Variations in final diagnosis including normal motility, IEM, absent peristalsis, distal esophageal spasm, hypercontractile motility, esophagogastric junction (EGJ) outflow obstruction, and achalasia are reported in Table 3.

Variation in High-resolution Manometry Final Diagnosis According to Body Position

Discussion

Even if different systems and catheters have been developed, current guidelines5 suggest performing HRM with the patient lying supine as it was done during the conventional manometry era.7 The supine position allows testing the peristaltic function without interference of gravity, but some authors argue that a seated position is more physiological and more similar to daily habits, thus increasing the diagnostic sensitivity. The present systematic review shows that a number of authors have analyzed and compared HRM patterns in the supine and upright/sitting positions, but the results have been inconclusive. Of the 10 studies11,13,16-18,21-24,26 conducted on healthy subjects, only 2 studies12,23 did not find significant differences concerning EGJ morphology. On the other hand, Buduhan et al11 and Hoppo et al15 found that the LES length was significantly shorter when the patients moved to the upright position, indicating that the LES barrier may be more effective in the supine position. Generally, the LES basal pressure resulted to be higher in the supine position. Zhang et al21 and Xiao et al16 speculated that higher IBP pressure and the gravity effect in the upright position may reduce LES pressures. Ciriza-de-Los-Ríos et al20 suggested that the increased LES basal pressure in the supine position is a protective mechanism against gastroesophageal reflux due to a concomitant increase of intragastric pressure. The decreased IRP value in the upright position may be due to the fact that gravity itself facilitates the esophageal emptying.16 On the contrary, in 3 studies13,18,22 higher IRP values have been found in the upright position. Sweis et al13 speculated that increased hydrostatic forces in the distal esophagus in the upright setting or changes in EGJ anatomy alter the resistance to flow. Besanko et al18 found a significantly higher IRP in the upright position in a cohort of healthy old adults, and hypothesized that impaired swallow-induced relaxation and/or loss of LES compliance secondary to age may explain this finding. Moreover, it has been reported that variables such as age and HRM software correlate with the IRP measure and could influence the final manometric diagnosis.22,23 Only Hashmi et al19 found that both LES length and pressures were significantly lower in the supine position, and hypothesized that the LES creates a stronger barrier to reflux and a greater resistance to bolus flow while in the sitting position. Moreover, dysphagia could be missed if patients are examined only when supine. All studies12,13,16-18,20,22-24,26 that analyzed esophageal body contraction vigor agree that the DCI is significantly greater in the supine position due to a higher resistance to flow typical of this position. Only Besanko et al18 found that older adults have significantly higher DCI in the sitting/upright position.

Overall, the diagnostic agreement in the final manometric diagnosis between the 2 positions varied from 67.6% to 90.0%.10,14,26 It should be noted that other factors could influence a change in diagnosis in patients undergoing HRM. In fact, reproducibility of HRM may represent the Achille’s heel of this technology, and when the test is repeated over time the diagnosis may change. Triadafilopoulos27 reported a 41.0% change in diagnosis in patients who had an initial normal study after a mean interval between studies of 15 months. In contrast, in the only patient with achalasia the diagnosis remained stable over time. This suggests that change in the final diagnosis may not be clinically relevant, and precautions must be taken in the interpretation of HRM findings.

There are some limitations in this study. First, the heterogeneity of subjects included into the analysis: some studies involved both healthy and symptomatic adults. This may introduce a significant bias due to the multiple factors that can affect the HRM results.6 Second, the studies considered in this review do not assume the same HRM classification or protocol in the assessment of results. Third, no studies considered the most recent HRM tools, such as multiple rapid swallows-DCI ratio and EGJ-contractile integral.28,29

Although the results of comparative studies analyzed in the present systematic review are still discordant, the upright/sitting position has more recently emerged as an alternative to the supine position, which appears to be uncomfortable for the patient and probably non-physiological.6 However, normal values are needed to establish the most adequate body position for HRM in order to increase the reproducibility of the test. Interestingly, at least 1 clinical study in gastroesophageal reflux disease patients30 and one non-comparative study31 in normal volunteers considered the semi-recumbent position with 30° sit-back inclination which may be as much as comfortable both for the patient and the physician. Additionally, in this pilot study, the results obtained were similar to those previously described by Pandolfino et al1 and Ghosh et al2,3 in the supine position. More trials should be performed to evaluate if the semi-recumbent or upright position could become the reference standard in the future.

In conclusion, performing HRM in the upright position affect some manometric variables that may change the final manometric diagnosis. Further studies to determine the normal manometric values and evaluate patient reported outcomes and compliance in the sitting and semi-recumbent positions are needed.

Acknowledgements

Acknowlegements: Work supported by AIRES (Associazione Italiana Ricerca ESofago).

Notes

Financial support: None.

Conflicts of interest: None.

Author contributions: Carlo G Riva, Stefano Siboni, Davide Ferrari, and Luigi Bonavina designed the study and wrote the manuscript; and Carlo G Riva, Davide Ferrari, Marco Sozzi, Matteo Capuzzo, Emanuele Asti, and Cristina Ogliari collected the data. All authors reviewed the final version of the manuscript.

References

1. Pandolfino JE, Ghosh SK, Zhang Q, Jarosz A, Shah N, Kahrilas PJ. 2006;Quantifying EGJ morphology and relaxation with high-resolution manometry: a study of 75 asymptomatic volunteers. Am J Physiol Gastrointest Liver Physiol 290:G1033–G1040.
2. Ghosh SK, Pandolfino JE, Zhang Q, Jarosz A, Shah N, Kahrilas PJ. 2006;Quantifying esophageal peristalsis with high-resolution manometry: a study of 75 asymptomatic volunteers. Am J Physiol Gastrointest Liver Physiol 290:G988–G997.
3. Ghosh SK, Pandolfino JE, Zhang Q, Jarosz A, Kahrilas PJ. 2006;Deglutitive upper esophageal sphincter relaxation: a study of 75 volunteer subjects using solid-state high-resolution manometry. Am J Physiol Gastrointest Liver Physiol 291:G525–G531.
4. Pandolfino JE, Ghosh SK, Rice J, Clarke JO, Kwiatek MA, Kahrilas PJ. 2008;Classifying esophageal motility by pressure topography characteristics: a study of 400 patients and 75 controls. Am J Gastroenterol 103:27–37.
5. Kahrilas PJ, Bredenoord AJ, Fox M, et al. 2015;The Chicago classification of esophageal motility disorders, v3.0. Neurogastroenterol Motil 27:160–174.
6. Herregods TV, Roman S, Kahrilas PJ, Smout AJ, Bredenoord AJ. 2015;Normative values in esophageal high-resolution manometry. Neurogastroenterol Motil 27:175–187.
7. Winans CS, Harris LD. 1967;Quantitation of lower esophageal sphincter competence. Gastroenterology 52:773–778.
8. Babaei A, Mittal RK. 2011;Cardiovascular compression of the esophagus and spread of gastro-esophageal reflux. Neurogastroenterol Motil 23:45–51. e3.
9. Murad MH, Sultan S, Haffar S, Bazerbachi F. 2018;Methodological quality and synthesis of case series and case reports. BMJ Evid Based Med 23:60–63.
10. ^^Bernhard A, Pohl D, Fried M, Castell DO, Tutuian R. 2008;Influence of bolus consistency and position on esophageal high-resolution manometry findings. Dig Dis Sci 53:1198–1205.
11. Buduhan G, Orlina J, Louie B, Vallieres E, Aye R. 2010;Endoscopic and manometric position-related characteristics of the normal gastroesophageal junction. Surg Endosc 24:2165–2169.
12. Roman S, Damon H, Pellissier PE, Mion F. 2010;Does body position modify the results of oesophageal high resolution manometry?. Neurogastroenterol Motil 22:271–275.
13. Sweis R, Anggiansah A, Wong T, Kaufman E, Obrecht S, Fox M. 2011;Normative values and inter-observer agreement for liquid and solid bolus swallows in upright and supine positions as assessed by esophageal high-resolution manometry. Neurogastroenterol Motil 23:509–e198.
14. Xiao Y, Nicodème F, Kahrilas PJ, Roman S, Lin Z, Pandolfino JE. 2012;Optimizing the swallow protocol of clinical high-resolution esophageal manometry studies. Neurogastroenterol Motil 24:e489–e496.
15. Hoppo T, Komatsu Y, Nieponice A, Schrenker J, Jobe BA. 2012;Toward an improved understanding of isolated upright reflux: positional effects on the lower esophageal sphincter in patients with symptoms of gastroesophageal reflux. World J Surg 36:1623–1631.
16. Xiao Y, Read A, Nicodème F, Roman S, Kahrilas PJ, Pandolfino JE. 2012;The effect of a sitting vs supine posture on normative esophageal pressure topography metrics and Chicago classification diagnosis of esophageal motility disorders. Neurogastroenterol Motil 24:e509–e516.
17. Zhang X, Xiang X, Tu L, Xie X, Hou X. 2013;Esophageal motility in the supine and upright positions for liquid and solid swallows through high-resolution manometry. J Neurogastroenterol Motil 19:467–472.
18. Besanko LK, Burgstad CM, Cock C, Heddle R, Fraser A, Fraser RJ. 2014;Changes in esophageal and lower esophageal sphincter motility with healthy aging. J Gastrointest Liver Dis 23:243–248.
19. Hashmi S, Rao SS, Summers RW, Schulze K. 2014;Esophageal pressure topography, body position, and hiatal hernia. J Clin Gastroenterol 48:224–230.
20. Ciriza-de-Los-Ríos C, Canga-Rodríguez-Valcárcel F, Lora-Pablos D, De-La-Cruz-Bértolo J, Castel-de-Lucas I, Castellano-Tortajada G. 2015;How the body position can influence high-resolution manometry results in the study of esophageal dysphagia and gastroesophageal reflux disease. J Neurogastroenterol Motil 21:370–379.
21. Zhang XJ, Xiang XL, Tu L, Xie XP, Hou XH. 2015;The effect of position on esophageal structure and function determined with solid-state high-resolution manometry. J Dig Dis 16:350–356.
22. Jung KW, Jung HY, Myung SJ, et al. 2015;The effect of age on the key parameters in the Chicago classification: a study using high-resolution esophageal manometry in asymptomatic normal individuals. Neurogastroenterol Motil 27:246–257.
23. do Carmo GC, Jafari J, Sifrim D, de Oliveira RB. 2015;Normal esophageal pressure topography metrics for data derived from the Sandhill-Unisensor high-resolution manometry assembly in supine and sitting positions. Neurogastroenterol Motil 27:285–292.
24. Hiranyatheb P, Chakkaphak S, Chirnaksorn S, Lekhaka P, Petsrikun K, Somboonpun K. 2018;Normal values of high-resolution manometry in supine and upright positions in a thai population. Dig Dis Sci 63:173–183.
25. Pu L, Chavalitdhamrong D, Summerlee RJ, Zhang Q. 2019;Jun. 25. Effects of posture and swallow volume on esophageal motility morphology and probability of bolus clearance: a study using high-resolution impedance manometry. Gastroenterol Nurs Published Online First doi: 10.1097/SGA.0000000000000356..
26. Misselwitz B, Hollenstein M, Bütikofer S, Ang D, Heinrich H, Fox M. 2020;Prospective serial diagnostic study: the effects of position and provocative tests on the diagnosis of oesophageal motility disorders by high-resolution manometry. Aliment Pharmacol Ther 51:706–718.
27. Triadafilopoulos G, Kamal A, Zikos T, Nguyen L, Clarke JO. 2020;Changes in high-resolution manometric diagnosis over time: implications for clinical decision-making. Dis Esophagus 33:doz094
28. Shaker A, Stoikes N, Drapekin J, Kushnir V, Brunt LM, Gyawali CP. 2013;Multiple rapid swallow responses during esophageal high-resolution manometry reflect esophageal body peristaltic reserve. Am J Gastroenterol 108:1706–1712.
29. Nicodème F, Pipa-Muniz M, Khanna K, Kahrilas PJ, Pandolfino JE. 2014;Quantifying esophagogastric junction contractility with a novel HRM topographic metric, the EGJ-contractile integral: normative values and preliminary evaluation in PPI non-responders. Neurogastroenterol Motil 26:353–360.
30. Riva CG, Siboni S, Sozzi M, Lazzari V, Asti E, Bonavina L. 2020;High-resolution manometry findings after Linx procedure for gastro-oesophageal reflux disease. Neurogastroenterol Motil 32e13750.
31. Niebisch S, Wilshire CL, Peters JH. 2013;Systematic analysis of esophageal pressure topography in high-resolution manometry of 68 normal volunteers. Dis Esophagus 26:651–660.

Article information Continued

Figure

The Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) diagram. UES, upper esophageal sphincter.

Table 1

Patients Characteristics and High-resolution Manometry Protocol Features

Author Subgroup Body position No. of patients Type of patients Patients position Manometric software
Bernhard et al10 Supine 96 Symptomatic Left lateral decubitus Trace! V1.2 videomanometry system; Hebbard System
Upright NR
Buduhan et al11 Supine 10 Healthy NR ManoView; Sierra Scientific Instruments
Upright NR
Roman et al12 Supine 100 Symptomatic NR ManoView; Sierra Scientific Instruments
Upright NR
Sweis et al13 Supine 21 Healthy NR ManoView; Sierra Scientific Instruments
Upright NR
Xiao et al14 Supine 148 Symptomatic 0-10° ManoView; Sierra Scientific Instruments
Upright 70-90°
Hoppo et al15 Isolated upright reflux Supine 35 Symptomatic NR Bioview; Sandhill
Upright NR
Predominant upright bipositional reflux Supine 53 NR
Upright NR
Predominant supine bipositional reflux Supine 27 NR
Upright NR
Xiao et al16 Healthy Supine 75 Healthy 0-10° ManoView; Given Imaging
Upright 70-90°
No hiatal hernia Supine 80 Symptomatic 0-10°
Upright 70-90°
Hiatal hernia Supine 40 Symptomatic 0-10°
Upright 70-90°
Zhang et al17 Volunteers Supine 21 Healthy 0-20° ManoView; Sierra Scientific Instruments
Upright 70-90°
Patients Supine 25 Symptomatic 0-20°
Upright 70-90°
Besanko et al18 Younger Supine 10 Healthy Right lateral decubitus Trace! V1.2 videomanometry system; Hebbard System
Upright NR
Older Supine 10 Healthy Right lateral decubitus
Upright NR
Hashmi et al19 Supine 50 Symptomatic 20° ManoView; Sierra Scientific Instruments
Upright NR
Ciriza-de-Los-Ríos et al20 Dysphagia group Supine 49 Symptomatic NR ManoView; Given Imaging
Upright NR
GERD group Supine 50 NR
Upright NR
Zhang et al21 Supine 50 Healthy and symptomatic patients NR ManoView; Sierra Scientific Instruments
Upright NR
Jung et al22 Supine 54 Healthy NR Bioview; Sandhill
Upright NR
Do Carmo et al23 Supine 69 Healthy NR Bioview; Sandhill
Upright NR
Hiranyatheb et al24 Supine 41 Healthy 10° ManoView; Sierra Scientific Instruments
Upright 80-90°
Pu et al25 Supine 139 Symptomatic NR ManoView; Given Imaging
Upright NR
Misselwitz et al26 Supine 72 Healthy NR ManoView; Sierra Scientific Instruments
Upright NR
Supine 366 Symptomatic NR
Upright NR

NR, not reported.

Table 2

High-resolution Manometry Findings in Healthy Subjects

Author Subgroup No. of patients Body position LES Esophageal body


Total length (cm) Basal pressure (mmHg) IRP (mmHg) DCI (mmHg∙sec∙cm) IBP (mmHg) DL (sec) Mean wave pressure (mmHg)
Buduhan et al11 10 Supine 3.1 ± 1.0 17.3 ± 8.9 NR NR NR NR 78.2
Upright 3.2 ± 0.7 16.1 ± 12.5 NR NR NR NR 78.4
P-value 0.730 0.800 0.970
Sweis et al13 46 Supine NR 18.9 (13.6) 3.8 ± 0.6 1303.4 ± 341.1 8.4 ± 1.0 NR 79.8 ± 8.2
Upright NR 22.9 (13.3) 6.2 ± 0.9 1058.7 ± 198.0 9.8 ± 1.1 NR 75.0 ± 7.2
P-value 0.516 0.004 0.287 NR
Xiao et al16 75 Supine NR NR 7.9 (4.7) 1612 (1062) NR 5.8 (1.3) NR
Upright NR NR 2.8 (4.3) 698 (597) NR 6.4 (1.5) NR
P-value < 0.001 < 0.001 < 0.001
Zhang et al17 Volunteers 21 Supine NR NR 7.6 ± 2.6 1596.9 ± 916.9 NR 6.4 ± 1.0 NR
Upright NR NR 5.5 ± 3.5 1259.0 ± 996.8 NR 5.9 ± 1.3 NR
P-value 0.017 0.008 0.023
Besanko et al18 Younger 10 Supine NR NR 2.6 ± 0.5 946.7 ± 201 NR NR 40.6 ± 7.5
Upright NR NR 3.1 ± 0.4 852.8 ± 190 NR NR 41.4 ± 6.2
P-value NR NR NR
Older 10 Supine NR NR 3.5 ± 0.9 834.8 ± 260 NR NR 37.6 ± 9.1
Upright NR NR 6.9 ± 1.1 1223.5 ± 292 NR NR 49.5 ± 8.7
P-value 0.010 0.006 0.007
Zhang et al21 50 Supine 3.4 ± 0.6 18.1 ± 7.8 7.8 ± 3.2 NR NR NR NR
Upright 3.3 ± 0.6 13.8 ± 5.9 5.6 ± 3.3 NR NR NR NR
P-value 0.192 < 0.001 < 0.001
Jung et al22 54 Supine NR NR 7.8 (11.8) 1372.9 (1347) NR 6.1 (1.2) NR
Upright NR NR 8.2 (5.1) 708.3 (864) NR 6.9 (1.0) NR
P-value 0.860 < 0.01 < 0.01
Do Carmo et al23 69 Supine 2.9 (1.1) 36.2 (21.7) 13.5 (8.2) 1785 (2018) 12.9 (5.7) 6.5 (1.5) NR
Upright 2.3 (0.7) 18.2 (12.6) 6.4 (6.3) 1176 (1361) 6.9 (6.2) 6.5 (1.7) NR
P-value 0.006 < 0.001 < 0.001 0.003 < 0.001 0.902
Hiranyatheb et al24 41 Supine NR 25.1 ± 10.3 7.5 ± 3.2 1274.6 ± 841.9 12.2 ± 3.6 6.3 ± 0.9 NR
Upright NR 20.4 ± 11.4 4.7 ± 3.4 1046.4 ± 754.4 9.8 ± 4.7 6.1 ± 1.0 NR
P-value < 0.001 < 0.001 0.003 < 0.001 0.087

LES, lower esophageal sphincter; IRP, integrated relaxation pressure; DCI, distal contractile integral; IBP, intrabolus pressure; CFV, contraction front velocity; DL, distal latency; NR, not reported.

Values are expressed as mean ± standard deviation or mean (interquartile range).

Table 3

Variation in High-resolution Manometry Final Diagnosis According to Body Position

Author Indications Body position Normal motility Ineffective motility Absent peristalsis DES Hypercontractile motility EGJ-OO Achalasia Non specific
Bernard et al10 GERD Supine 71 19 NR 6 NR NR NR NR
Upright 58 32 NR 6 NR NR NR NR
Roman et al12 GERD, dysphagia, systemic sclerosis, post-fundoplication, Supine 36 35 4 10 2 9 4 NR
Upright 25 47 7 8 2 7 4 NR
Xiao et al14 NR Supine 39 NR NR NR NR 12 8 NR
Upright 22 NR NR NR NR 16 7 NR
Ciriza-de-Los-Ríos et al20 Dysphagia Supine 25 7 2 6 1 NR 2 3
Upright 17 10 2 12 0 NR 2 2
GERD Supine 29 9 0 9 0 NR 0 3
Upright 21 16 0 10 0 NR 0 2
Hiranyatheb et al24 Healthy subjects Supine NR 5 NR NR NR NR NR NR
Upright NR 10 NR NR NR NR NR NR
Misselwitz et al26 Healthy subjects, foregut symptoms Supine 278 89 29 8 4 20 10 NR
Upright 197 172 41 9 4 4 11 NR

DES, distal esophageal spasm; EGJ-OO, esophagogastric junction outflow obstruction; NR, not reported; GERD, gastroesophageal reflux disease.